Research progress of biosensors based on long period fiber grating
doi: 10.3788/CO.20181103.0475
-
摘要: 长周期光纤光栅是对周围环境比较敏感的一种无源光学器件，由于其具有无后向反射、对折射率灵敏度高、体积小、易于集成化、不受电磁干扰、耐酸碱腐蚀、不需要参比电极等诸多特点，在折射率传感领域备受关注。自从2000年Bentley研究组第一次将长周期光纤光栅用于抗原的检测以来，经过十余年的发展，长周期光栅在生物物质的检测方面取得了很大的进展，已被用于抗原抗体、细菌病毒、蛋白质、DNA、酶及核酸等诸多生物物质的检测。本文对长周期光纤光栅近年来在生物传感领域的研究进展和应用进行了总结和评述，并对长周期光纤光栅在生物物质检测方面的未来发展趋势做了展望。Abstract: Long period fiber grating is a kind of passive optical device which is sensitive to the surrounding environment. Owing to without retroreflection, high sensitivity to refractive index, miniature size, easy integration, immunity to electromagnetic interference, non-corrosiveness, without the need of reference electrode, long period fiber grating based optical sensors have attracted much attention in the field of refractive index sensing. Since Bentley research group first used long period fiber gratings to detect antigens in 2000, long-period gratings have made great progress in the detection of biological substances in recent years and have been utilized for the detection of many biological substances such as antigen-antibody, bacterial viruses, proteins, DNA, enzymes, nucleic acids, and so on. In this paper, the research progress and applications of long period fiber grating in the biosensing field in recent years are summarized and reviewed, and the future development trend of long period fiber grating in biological detection is also prospected.
-
Key words:
- long period fiber grating /
- biotechnology /
- detection /
- sensor /
- progress
-
图 1 生化试剂在光子晶体光纤-长周期光栅表面作用时所引起的谐振波长移动情况
Figure 1. Shift of resonance wavelength of the LPFG-PCF at various surface events
图 2 涂覆二氧化钛-二氧化硅的长周期光栅生物传感结构示意图
Figure 2. Schematic illustration of the optical fiber biosensor based on titania-silica coated LPFG
图 3 长周期光栅检测DNA过程示意图
Figure 3. Schematic representation of DNA detection process using LPFG
图 4 长周期光栅表面不同生物试剂修饰示意图
Figure 4. Sketch of coated LPFG interface with different biological agents
图 5 磷酸缓冲液中浓度为109 CFU/mL的大肠杆菌在长周期光栅表面固定后的扫描电镜图
Figure 5. SEM micrograph of the E.coli immobilized on the surface of the LPFG:109 CFU/mL of E.coli concentration in PBS
图 6 长周期光栅表面修饰步骤及噬菌体T7检测示意图
Figure 6. Schematic representation of the LPFG surface modification steps and phage T7 detection
-
[1] CHO Y, AHMED F, JOE H E, et al.. Fabrication of a screw-shaped long-period fiber grating for refractive index sensing[J]. IEEE Photonics Technology Letters, 2017, 29(24):2242-2245. doi: 10.1109/LPT.2017.2765598 [2] SHANG R B, ZHANG W G, ZHU W B, et al.. Fabrication of twisted long period fiber gratings with high frequency CO2 laser pulses and its bend sensing[J]. Journal of Optics, 2013, 15(7):075402. doi: 10.1088/2040-8978/15/7/075402 [3] ZHANG C, CHENG L, FU S, et al.. Long period fiber grating fabrication by two-step infrared femtosecond fiber laser exposure[J]. IEEE Photonics Journal, 2017, 9(3):7104908. [4] LI Q, ZHANG X L, YU Y S, et al.. Enhanced sucrose sensing sensitivity of long period fiber grating by self-assembled polyelectrolyte multilayers[J]. Reactive and Functional Polymers, 2011, 71:335-339. doi: 10.1016/j.reactfunctpolym.2010.11.012 [5] LI Q SH, XIANG D, CHEN CH, et al.. Transmission mode measurement technique of long period grating based on a single end face[J]. Chinese Journal of Luminescence, 2017, 38(8):1090-1096.(in Chinese) doi: 10.3788/fgxb [6] PILLA P, TRONO C, BALDINI F, et al.. Giant sensitivity of long period gratings in transition mode near the dispersion turning point:an integrated design approach[J]. Optics Letters, 2012, 37(19):4152-4154. doi: 10.1364/OL.37.004152 [7] LIANG J F, JING SH M, MENG A H, et al.. Integrated optical sensor based on a FBG in parallel with a LPG[J]. Chinese Optics, 2016, 9(3):329-334.(in Chinese) doi: 10.3788/co. [8] LI Q S, ZHANG X L, SHI J G, et al.. An ultrasensitive long-period fiber grating-based refractive index sensor with long wavelengths[J]. Sensors, 2016, 16(12):2205. doi: 10.3390/s16122205 [9] LI Q S, ZHANG X L, HE H, et al.. Improved detecting sensitivity of long period fiber gratings by polyelectrolyte multilayers:the effect of film structures[J]. Optics Communications, 2014, 331:39-44. doi: 10.1016/j.optcom.2014.05.046 [10] SUN B CH, HOU Y M, LI F, et al.. Coupling characteristics between fiber grating and stimulated Brillouin signal[J]. Chinese Optics, 2017, 10(4):484-490.(in Chinese) doi: 10.3788/co. [11] LAN CH G, WANG T H, LIU H, et al.. Development and application of FBG retard-bonded smart steel strands[J]. Journal of Harbin Institute of Technology, 2014, 46(6):100-104.(in Chinese) [12] JING SH M, ZHANG X Y, LIANG J F, et al.. Ultrashort fiber Bragg grating written by femtosecond laser and its sensing characteristics[J]. Chinese Optics, 2017, 10(4):449-454.(in Chinese) doi: 10.3788/co. [13] LIU B, LIU H, LIN J, et al.. High sensitivity Fabry-Perot fiber acoustic pressure sensor based on large area silver diaphragm[J]. Journal of Harbin Institute of Technology, 2016, 48(3):11-14.(in Chinese) [14] JIN L, LI M, HE J J. Optical waveguide double-ring sensor using intensity interrogation with a low-cost broadband source[J]. Optics Letters, 2011, 36(7):1128-1130. doi: 10.1364/OL.36.001128 [15] LIU J, ZHOU X, QIAO Z, et al.. Integrated optical chemical sensor based on an SOI ring resonator using phase-interrogation[J]. IEEE Photonics Journal, 2014, 6(5):1-7. [16] LIU X F, ZHANG X R, LAN G Q, et al.. Thermal index based on surface plasmon resonance[J]. Acta Optica Sinica, 2016, 36(05):250-257.(in Chinese) [17] WANG ZH B, HAN H H, CHAI J F, et al.. Prism surface plasmons resonance sensor based on the porous silicon[J]. Chinese Journal of Luminescence, 2016, 37(9):1152-1158.(in Chinese) doi: 10.3788/fgxb [18] ZHU Y CH, YUAN W ZH, YU Y T. Planar plasmonic lenses and their applications[J]. Chinese Optics, 2017, 10(2):149-163. (in Chinese) doi: 10.3788/co. [19] LI Q SH, CHENG R, ZHANG X L, et al.. Modulation of polymer thin films on surface plasmon resonance spectroscopy[J]. Journal of Zhejiang University(Engineering Science), 2015, 49(9):1796-1804.(in Chinese) https://www.researchgate.net/publication/283646227_Modulation_of_polymer_thin_films_on_surface_plasmon_resonance_spectroscopy [20] YANG Y, HE H, LI Q SH, et al.. TiO2 nanowire array based interferometric sensor[J]. Chinese Optics, 2014, 7(3):421-427.(in Chinese) http://www.chineseoptics.net.cn/CN/abstract/abstract9145.shtml [21] LI Q S, XIANG D, CHANG Z M, et al.. Highly sensitive refractive index sensor based on a TiO2 nanowire array[J]. Applied Optics, 2017, 56(7):1930-1934. doi: 10.1364/AO.56.001930 [22] LI J, LI M M, SUN L P, et al.. Polarization-maintaining microfiber-based evanescent-wave sensors[J]. Acta Physica Sinica, 2017, 66(7):74209.(in Chinese) [23] FALCIAI R, MIGNANI A G, VANNINI A. Long period gratings as solution concentration sensors[J]. Sensors and Actuators B:Chemical, 2001, 74(1):74-77. http://cn.bing.com/academic/profile?id=7a95267a343b6eee31942e9fcf2e7bd0&encoded=0&v=paper_preview&mkt=zh-cn [24] DELISA M P, ZHANG Z, SHILOACH M, et al.. Evanescent wave long-period fiber bragg grating as an immobilized antibody biosensor[J]. Analytical Chemistry, 2000, 72(13):2895-900. doi: 10.1021/ac9912395 [25] KIM D, ZHANG Y, KL COOPER, et al.. Fibre-optic interferometric immuno-sensor using long period grating[J]. Electronics Letters, 2006, 42(6):324-325. doi: 10.1049/el:20060040 [26] HE Z, TIAN F, ZHU Y, et al.. Long-period gratings in photonic crystal fiber as an optofluidic label-free biosensor[J]. Biosensors and Bioelectronics, 2011, 26(12):4774-4778. doi: 10.1016/j.bios.2011.05.048 [27] CHIAVAIOLI F, TRONO C, GIANNETTI A, et al.. Characterisation of a label-free biosensor based on long period grating[J]. Journal of Biophotonics, 2014, 7(5):312-322. doi: 10.1002/jbio.v7.5 [28] CHIAVAIOLI F, BISWAS P, TRONO C, et al.. Towards sensitive label-free immunosensing by means of turn-around point long period fiber gratings[J]. Biosensors and Bioelectronics, 2014, 60:305-310. doi: 10.1016/j.bios.2014.04.042 [29] CHIAVAIOLI F, BISWAS P, TRONO C, et al.. Sol-gel-based titania-silica thin film overlay for long period fiber grating-based biosensors[J]. Analytical Chemistry, 2015, 87(24):12024-12031. doi: 10.1021/acs.analchem.5b01841 [30] PILLA P, SANDOMENICO A, MALACHOVSK V, et al.. A protein-based biointerfacing route toward label-free immunoassays with long period gratings in transition mode[J]. Biosensors and Bioelectronics, 2012, 31(1):486-491. doi: 10.1016/j.bios.2011.11.022 [31] BISWAS P, CHIAVAIOLI F, JANA S, et al. . Manufacturing and optimization of sol-gel-based TiO2-SiO2 thin films as high refractive index overlays for long period grating-based biosensing[C]. International Conference on Photonics, Optics and Laser Technology, IEEE, 2017: 349-355. [32] BISWAS P, CHIAVAIOLI F, JANA S, et al.. Design, fabrication and characterisation of silica-titania thin film coated over coupled long period fibre gratings:Towards bio-sensing applications[J]. Sensors and Actuators B:Chemical, 2017, 253:418-427. doi: 10.1016/j.snb.2017.06.139 [33] QUERO G, CONSALES M, SEVERINO R, et al. . High sensitive long period fiber grating biosensor for cancer biomarker detection[C]. Proceedings of the International Joint Conference on Biomedical Engineering Systems and Technologies. SCITEPRESS-Science and Technology Publications, Lda, 2016: 561-569. [34] QUERO G, CONSALES M, SEVERINO R, et al.. Long period fiber grating nano-optrode for cancer biomarker detection[J]. Biosensors and Bioelectronics, 2016, 80:590-600. doi: 10.1016/j.bios.2016.02.021 [35] TANG J L, WANG J N. Chemical sensing sensitivity of long-period grating sensor enhanced by colloidal gold nanoparticles[J]. Sensors, 2008, 8(1):171-184. doi: 10.3390/s8010171 [36] TANG J L, CHENG S F, HSU W T, et al.. Fiber-optic biochemical sensing with a colloidal gold-modified long period fiber grating[J]. Sensors and Actuators B:Chemical, 2006, 119(1):105-109. doi: 10.1016/j.snb.2005.12.003 [37] SOZZI M, COSCELLI E, POLI F, et al. . Long period grating-based fiber optic sensor for label-free DNA detection[C]. 2011 International Workshop on BioPhotonics, IEEE, 2011: 1-3. [38] CHRYSSIS A N, SAINI S S, LEE S M, et al.. Detecting hybridization of DNA by highly sensitive evanescent field etched core fiber Bragg grating sensors[J]. IEEE Journal of selected topics in Quantum Electronics, 2005, 11(4):864-872. doi: 10.1109/JSTQE.2005.857724 [39] CHEN X, ZHANG L, ZHOU K, et al.. Real-time detection of DNA interactions with long-period fiber-grating-based biosensor[J]. Optics Letters, 2007, 32(17):2541-2543. doi: 10.1364/OL.32.002541 [40] CHEN X, HUGHES M, ZHOU K, et al. . Long-period fibre grating based biosensor for detection of DNA hybridization[C]. Bragg Gratings, Photosensitivity, and Poling in Glass Waveguides. Optical Society of America, USA, 2007: BTuE4. [41] DELGADO-PINAR M, SHI Q, POVEDA-WONG L, et al.. Oligonucleotide-hybridization fiber-optic biosensor using a narrow bandwidth long period grating[J]. IEEE Sensors Journal, 2017, 17(17):5503-5509. doi: 10.1109/JSEN.2017.2723759 [42] JANG H S, PARK K N, KIM J P, et al.. Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface[J]. Optics Express, 2009, 17(5):3855-3860. doi: 10.1364/OE.17.003855 [43] RINDORF L, JENSEN J B, DUFVA M, et al.. Photonic crystal fiber long-period gratings for biochemical sensing[J]. Optics Express, 2006, 14(18):8224-8231. doi: 10.1364/OE.14.008224 [44] CHEN X, LIU C, HUGHES M D, et al.. EDC-mediated oligonucleotide immobilization on a long period grating optical biosensor[J]. Journal of Biosensors and Bioelectronics, 2015, 6:173.doi: 10.4172/2155-6210.1000173. [45] GONÇALVES H M R, MOREIRA L, PEREIRA L, et al.. Biosensor for label-free DNA quantification based on functionalized LPGs[J]. Biosensors and Bioelectronics, 2016, 84:30-36. doi: 10.1016/j.bios.2015.10.001 [46] PILLA P, MANZILLO P F, MALACHOVSKA V, et al. . Development of a platform for biochemical sensing based on overlayered Long Period Gratings working in transition[C]. Sensors, 2009 IEEE. IEEE, 2009: 361-366. [47] PILLA P, MANZILLO P F, MALACHOVSKA V, et al.. Long period grating working in transition mode as promising technological platform for label-free biosensing[J]. Optics Express, 2009, 17(22):20039-20050. doi: 10.1364/OE.17.020039 [48] PILLA P, MALACHOVSKA V, BORRIELLO A, et al.. Transition mode long period grating biosensor with functional multilayer coatings[J]. Optics Express, 2011, 19(2):512-526. doi: 10.1364/OE.19.000512 [49] WANG Z Y, HEFLIN J R, KEVIN VAN COTT, et al.. Biosensors employing ionic self-assembled multilayers adsorbed on long-period fiber gratings[J]. Sensors and Actuators B:Chemical, 2009, 139:618-623. doi: 10.1016/j.snb.2009.02.073 [50] MAGUIS S, LAFFONT G, FERDINAND P, et al.. Biofunctionalized tilted Fiber Bragg Gratings for label-free immunosensing[J]. Optics Express, 2008, 16(23):19049-19062. doi: 10.1364/OE.16.019049 [51] MARQUES L, HERNANDEZ F U, JAMES S W, et al.. Highly sensitive optical fibre long period grating biosensor anchored with silica core gold shell nanoparticles[J]. Biosensors and Bioelectronics, 2016, 75:222-231. doi: 10.1016/j.bios.2015.08.046 [52] SMIETANA M, BOCK W J, MIKULIC P, et al.. Detection of bacteria using bacteriophages as recognition elements immobilized on long-period fiber gratings[J]. Optics Express, 2011, 19(9):7971-7978. doi: 10.1364/OE.19.007971 [53] TRIPATHI S M, BOCK W J, MIKULIC P, et al.. Long period grating based biosensor for the detection of Escherichia coli bacteria[J]. Biosensors and Bioelectronics, 2012, 35:308-312. doi: 10.1016/j.bios.2012.03.006 [54] BRZOZOWSKA E, ŚMIETANA M, KOBA M, et al.. Recognition of bacterial lipopolysaccharide using bacteriophage-adhesin-coated long-period gratings[J]. Biosensors and Bioelectronics, 2015, 67:93-99. doi: 10.1016/j.bios.2014.07.027 [55] BRZOZOWSKA E, KOBA M, ŚMIETANA M, et al.. Label-free Gram-negative bacteria detection using bacteriophage-adhesin-coated long-period gratings[J]. Biomedical Optics Express, 2016, 7(3):829-840. doi: 10.1364/BOE.7.000829 [56] DANDAPAT K, TRIPATHI S M, CHINIFOOROSHAN Y, et al.. Compact and cost-effective temperature-insensitive bio-sensor based on long-period fiber gratings for accurate detection of E. coli bacteria in water[J]. Optics Letters, 2016, 41(18):4198-4201. http://cn.bing.com/academic/profile?id=f60591826eb1cc451ca770185f1174a6&encoded=0&v=paper_preview&mkt=zh-cn [57] SMIETANA M, KOBA M, BRZOZOWSKA E, et al.. Label-free sensitivity of long-period gratings enhanced by atomic layer deposited TiO2 nano-overlays[J]. Optics Express, 2015, 23(7):8441-8453. doi: 10.1364/OE.23.008441 [58] KOBA M, ŚMIETANA M, BRZOZOWSKA E, et al. . Detection specificity studies of bacteriophage adhesin-coated long-period grating-based biosensor[C]. 24th International Conference on Optical Fibre Sensors. International Society for Optics and Photonics, 2015, 9634: 963426. [59] JANCZUK-RICHTER M, DOMINIK M, ROŹNIECKA E, et al.. Long-period fiber grating sensor for detection of viruses[J]. Sensors and Actuators B:Chemical, 2017, 250:32-38. doi: 10.1016/j.snb.2017.04.148 [60] COOPER K L, BANDARA A B, WANG Y, et al.. Photonic biosensor assays to detect and distinguish subspecies of Francisella tularensis[J]. Sensors, 2011, 11(3):3004-3019. doi: 10.3390/s110303004 [61] BANDARA A B, ZUO Z, RAMACHANDRAN S, et al.. Detection of methicillin-resistant staphylococci by biosensor assay consisting of nanoscale films on optical fiber long-period gratings[J]. Biosensors and Bioelectronics, 2015, 70:433-440. doi: 10.1016/j.bios.2015.03.041 [62] GAMBHIR M, GUPTA S, JOHN P, et al.. Detection of fungi using a long-period fibre grating[J]. Ukrainian Journal of Physical Optics, 2017, 18(2):77-82. doi: 10.3116/16091833/18/2/77/2017 [63] COELHO L, DE ALMEIDA J M M M, SANTOS J L, et al.. Aptamer-based fiber sensor for thrombin detection[J]. Journal of Biomedical Optics, 2016, 21(8):087005-087005. doi: 10.1117/1.JBO.21.8.087005 [64] CARRASQUILLA C, XIAO Y, XU C Q, et al.. Enhancing sensitivity and selectivity of long-period grating sensors using structure-switching aptamers bound to gold-doped macroporous silica coatings[J]. Analytical Chemistry, 2011, 83(20):7984-7991. doi: 10.1021/ac2020432 [65] QUEIR S R B, GOUVEIA C, FERNANDES J R, et al.. Evanescent wave DNA-aptamer biosensor based on long period gratings for the specific recognition of E. coli outer membrane proteins[J]. Biosensors and Bioelectronics, 2014, 62(5):227-233. http://cn.bing.com/academic/profile?id=8aa587fc2e547fb55ea7588e77028552&encoded=0&v=paper_preview&mkt=zh-cn [66] CHEN X, ZHOU K, ZHANG L, et al. . High sensitivity biosensor based on dual-peak LPG sensitised by light cladding etching[C]. 17th International Conference on Optical Fibre Sensors. International Society for Optics and Photonics, 2005, 5855: 383-387. [67] FICEK M, NIEDZIAŁKOWSKI P, ŚMIETANA M, et al.. Linear antenna microwave chemical vapour deposition of diamond films on long-period fiber gratings for bio-sensing applications[J]. Optical Materials Express, 2017, 7(11):3952. doi: 10.1364/OME.7.003952 [68] QUERO G, ZUPPOLINI S, CONSALES M, et al.. Long period fiber grating working in reflection mode as valuable biosensing platform for the detection of drug resistant bacteria[J]. Sensors and Actuators B:Chemical, 2016, 230:510-520. doi: 10.1016/j.snb.2016.02.086 [69] BALIYAN A, SITAL S, TIWARI U, et al.. Long period fiber grating based sensor for the detection of triacylglycerides[J]. Biosensors and Bioelectronics, 2016, 79:693-700. doi: 10.1016/j.bios.2015.12.089 [70] YANG R, DONG W, MENG X, et al.. Nanoporous TiO2/polyion thin-film-coated long-period grating sensors for the direct measurement of low-molecular-weight analytes[J]. Langmuir, 2012, 28(23):8814-8821. doi: 10.1021/la301445h [71] DEEP A, TIWARI U, KUMAR P, et al.. Immobilization of enzyme on long period grating fibers for sensitive glucose detection[J]. Biosensors and Bioelectronics, 2012, 33(1):190-195. doi: 10.1016/j.bios.2011.12.051 -
下载:
点击查看大图
图(7)
计量
- 文章访问数: 2719
- HTML全文浏览量: 1003
- PDF下载量: 226
- 被引次数: 0
