金纳米星诊疗剂的光热特性及其在光热治疗和光学相干层析成像中的应用研究

吴哲; 陆冬筱; 李金华

doi:10.37188/CO.2021-0205

Volume 15 Issue 2

Mar. 2022

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Chinese Optics > 2022 > 15(2): 233-241.

WU Zhe, LU Dong-xiao, LI Jin-hua. Photothermal properties of gold nanostars therapeutic agent and its application in photothermal therapy and optical coherence tomography[J]. Chinese Optics, 2022, 15(2): 233-241. doi: 10.37188/CO.2021-0205

Citation:

WU Zhe, LU Dong-xiao, LI Jin-hua. Photothermal properties of gold nanostars therapeutic agent and its application in photothermal therapy and optical coherence tomography[J]. Chinese Optics, 2022, 15(2): 233-241. doi: 10.37188/CO.2021-0205

Citation:

WU Zhe, LU Dong-xiao, LI Jin-hua. Photothermal properties of gold nanostars therapeutic agent and its application in photothermal therapy and optical coherence tomography[J]. Chinese Optics, 2022, 15(2): 233-241. doi: 10.37188/CO.2021-0205

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Photothermal properties of gold nanostars therapeutic agent and its application in photothermal therapy and optical coherence tomography

doi: 10.37188/CO.2021-0205

WU Zhe^{1, 2
,},
LU Dong-xiao^{1, 2
,
,},
LI Jin-hua^{1, 2
,
,}

1.
College of Physics, Changchun University of Science and Technology, Changchun 130022, China
2.
Nanophotonics and Biophotonics Key Laboratory of Jilin Province, Changchun 130022, China

Funds: Supported by Developing Project of Science and Technology of Jilin Province (No. 20210101155JC); National Natural Science Foundation of China (No. 62174015); the “111” Project of China (No. D17017); Project of Education Department of Jilin Province(No. JJKH20200730KJ, No. JJKH20210798KJ)

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Corresponding author: ludongxiao@cust.edu.cn; lijh@cust.edu.cn
Received Date: 25 Nov 2021
Rev Recd Date: 16 Dec 2021
Accepted Date: 12 Feb 2022

Available Online: 15 Feb 2022

Publish Date: 21 Mar 2022

Abstract

Abstract

In order to develop an excellent Au nanostars therapeutic agent for photothermal therapy and optical coherence tomography, we research the preparation of gold nanostars, photothermal properties, photothermal therapy and applications in optical coherence tomography. By adopting the tip structure to enhance the local surface plasmon resonance properties of gold nanomaterials, the multi-branched Au nanostars is prepared by seed mediated method. The multi-tip structure enables the Au nanostars to have obvious photothermal effect, then its effect as a therapeutic agent for photothermal therapy and contrast agent for optical coherence tomography is explored. The experimental results showed that compared with Au nanoparticles, the multi-branched Au nanostars had a higher photothermal conversion efficiency of 42%, and has good biocompatibility. At the concentration of 100 μg/mL, the survival rate of human breast cancer cells is 82%. Human breast cancer cells are effectively killed by laser irradiation at the concentration of 100 μg/mL, and the survival rate is significantly reduced to 37%. At the same time, Au nanostars also has better optical coherence tomography imaging effect, significantly improving the signal intensity and imaging depth. Au nanostars is a promising multifunctional therapeutic agent with both efficient photothermal therapy and excellent optical coherence tomography imaging capability.
- gold nanostars,
- photothermal therapy,
- optical coherence tomography

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