In this paper, we describe the mechanism of chiral negative refraction phenomenon, and summarize the research progress on simulations and experiments of metamaterial in recent years. Meanwhile, we analysis the optical activity, chiral parameters, losses and so on, and introduce the applications of chiral negative refraction materials in various fields. According to the analysis, we believe that it is one of important development directions for chiral negative refractive index materials to explore new mechanism, new methods and new materials, so as to achieve negative refraction in visible range in the future.