Volume 11 Issue 3
Jun.  2018
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Chinese Optics  > 2018  >  11(3): 513-530.
WANG Zhi-le, WANG Zhu-yuan, ZONG Shen-fei, CUI Yi-ping. Microfluidic SERS chip and its biosensing applications[J]. Chinese Optics, 2018, 11(3): 513-530. doi: 10.3788/CO.20181103.0513
Citation: WANG Zhi-le, WANG Zhu-yuan, ZONG Shen-fei, CUI Yi-ping. Microfluidic SERS chip and its biosensing applications[J]. Chinese Optics, 2018, 11(3): 513-530. doi: 10.3788/CO.20181103.0513
shu

Microfluidic SERS chip and its biosensing applications

  • Advanced Photonic Center, Southeast University, Nanjing 210096, China

Funds:

the Natural Science Foundation of China 61535003

the National Key Basic Research Program of China 2015CB352002

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  • Corresponding author: WANG Zhu-yuan, E-mail:wangzy@seu.edu.cn; CUI Yi-ping, E-mail:cyp@seu.edu.cn
  • Received Date: 03 Jan 2018
  • Rev Recd Date: 29 Jan 2018
  • Publish Date: 01 Jun 2018
    Abstract
  • With excellent integrability and flexible operability, microfluidic chips have been developed rapidly. Among them, Surface-enhanced Raman Spectroscopy (SERS) has become a widely used detection technique due to its ultrasensitivity, unique fingerprint spectrum and narrow spectroscopic bands. The SERS microfluidic chip integrates the advantages of the SERS detection technology and the microfluidic chip. On the one hand, it provides an efficient platform for the repeatability and reliability of the SERS detection method. On the other hand, it promotes function expansion for microfluidic chips. The SERS microfluidic chips have broad application prospects in the fields of biomolecule detection, cell capture and even tissue simulation. In this review, the principle of SERS is briefly introduced, and the construction of SERS microfluidic chip and its applications in biosensing and detection are emphatically summarized. Finally, the problems and development direction of the research are proposed.

     

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