Volume 11 Issue 3
Jun.  2018
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Chinese Optics  > 2018  >  11(3): 444-458.
SUN Rui, GAO Yin-jia, SHI Hai-bin. Advances in biological application of photo-crosslinking technique[J]. Chinese Optics, 2018, 11(3): 444-458. doi: 10.3788/CO.20181103.0444
Citation: SUN Rui, GAO Yin-jia, SHI Hai-bin. Advances in biological application of photo-crosslinking technique[J]. Chinese Optics, 2018, 11(3): 444-458. doi: 10.3788/CO.20181103.0444
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Advances in biological application of photo-crosslinking technique

  • State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China

Funds:

National Program on Key Basic Research Projects of China 2016YFC0101200

National Natural Science Foundation of China 21572153

Major projects of Natural Science Research in Universities in Jiangsu Province 15KJA310004

Science and Technology Plan of Suzhou City SYG201520

More Information
  • Corresponding author: SHI Hai-bin, E-mail:hbshi@suda.edu.cn
  • Received Date: 19 Jan 2018
  • Rev Recd Date: 13 Feb 2018
  • Publish Date: 01 Jun 2018
    Abstract
  • Photo-crosslinking technique is widely used in different research fields such as chemistry, biology, medicine and materials as a fast, simple and space-time controlled cross-linking tool. In this paper, the structure, classification and reaction mechanism of commonly used small-molecule photo-crosslinking groups are introduced in detail. The application of photo-crosslinking technique in biomedical fields is reviewed in detail, and the prospects for its application are assessed. Currently, most of the photo-crosslinking groups are only sensitive to ultraviolet and visible light, and have weak UV and visible light penetrating power, strong tissue absorption and scattering, which seriously limit the application of this technology in living system. Therefore, further research on the application of photo-crosslinking technology in biological systems and the development of new long-wavelength light-mediated crosslinking (such as near-infrared or far-infrared light) have important scientific significance for drug development and disease theranostics.

     

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