便携式双波段荧光眼底血管造影仪的光学设计

葛婧菁

doi:10.3788/CO.20130602.0223

便携式双波段荧光眼底血管造影仪的光学设计

doi: 10.3788/CO.20130602.0223

葛婧菁^,

北京空间机电研究所,北京 100190

基金项目:

国家自然科学基金资助项目(No.60978068)

详细信息

作者简介:
葛婧菁(1984—),女,黑龙江绥芬河人,博士,工程师,2011年于南开大学获得博士学位,主要从事光学系统设计和航空相机系统等方面的研究。E-mail:gejingjing977@gmail.com

通讯作者:
葛婧菁, E-mail:gejingjing977@gmail.com

中图分类号: TH773;R814.4
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出版历程
- 收稿日期: 2012-12-15
- 修回日期: 2013-02-22
- 刊出日期: 2013-04-10

Optical design of portable dual-band fluorescence fundus angiography

GE Jing-jing^,

Beijing Institute of Space Mechanics &Electricity, Beijing 100190, China

摘要

摘要: 基于Gullstrand-Le Grand眼模型设计了一款便携式双波段眼底造影仪的光学结构。考虑人眼光学系统的像差并使用共轴式照明,设计了在主波段525和826 nm下全视场200万像素高清晰成像的光学系统,该系统可实现吲哚菁绿血管造影和荧光眼底血管造影两种方式成像。为了避免角膜中心具有大曲率而引入杂散光,照明系统采用环形光阑、中空反射镜和共轴式照明相结合的方法。为了达到系统的便携性和成像清晰性,在摄影系统中加入两个非球面结构。实验结果表明:本系统具有较大的调节能力,对-10 m-1～+8 m-1人眼普遍适用,系统可实现30的眼底拍摄,眼底分辨率108 lp/mm,畸变10%,达到了便携式双波段眼底造影仪的使用要求。
- 医疗器械 /
- 眼底造影 /
- 眼模型 /
- 非球面
Abstract: An optical system of portable fundus angiography in dual-bands is designed based on the Gullstrand-Le Grand eye model. By considering the human vision system and applying the coaxial illumination, the apparatus with 2 mega pixels in all fields of view is designed, which can be used in Fundus Fluorescein Angiography(FFA) and Indocyanine Green Angiography(ICGA) under the wave bands of 525 nm and 826 nm. An annular diaphragm, a hollow mirror and a coaxial illumination are adopted in the illuminating system to avoid the stray light caused by the reflection of the corneal surface. Furthermore, two aspheric surfaces are involved in order to simplify the photographic system. The result shows that with a larger accommodation, this system can adapts to human eyes from -10 m-1 to +8 m-1. With the field of view of 30, the resolution of the eyeground over 108 lp/mm, and the distortion value less than 10% the system can satisfy the requirements as a portable dual-band imaging instrument.
- medical equipment /
- fundus angiography /
- eye model /
- aspheric surface

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参考文献(1)

[1] SU Z,YE P,TENG Y,et al.. Adverse reaction in patients with drug allergy history after simultaneous intravenous fundus fluorescein angiography and indocyanine green angiography[J]. J. Ocul. Pharmacol. Ther.,2012,28(4):410-413. [2] YANNUZZI L A,SLAKTER J S,GROSS N E,et al.. Indocyanine green angiography-guided photodynamic therapy for treatment of chronic central serous chorioretinopathy:a pilot study[J]. Retina.,2012,2(32):288-298. [3] BAGLIO V,GHARBIYA M,BALACCO-GABRIELI C,et al..Choroidopathy in patients with systemic lupus erythematosus with or without nephropathy[J]. J Nephrol.,2011,24(4):522-529. [4] GHARBIYA M,BOZZONI-PANTALEONI F,AUGELLO F,et al.. Indocyanine green angiographic findings in systemic lupus erythematosus choroidopathy[J]. Am J Ophthalmol.,2002,134(2):286-290. [5] 惠延年.眼科学[M].6版.北京:人民卫生出版社,2005. HUI Y N. Ophthalmology[M]. 6th ed. Beijing:People's Health Publishing House,2005.(in Chinese) [6] 叔仁,张晓峰.临床眼底病学[M].合肥:安徽科学技术出版社,1994. SHU R,ZHANG X F. Clinical Fundus School[M]. Hefei:Anhui Science and Technology Press,1994.(in Chinese) [7] 施玉英.眼底病[M].北京:华夏出版社,1999. SHI Y Y. Ocular Fundus[M]. Beijing:China Press,1999.(in Chinese) [8] 王肇圻,许妍.基于眼模型的数字眼底相机设计[J].光学精密工程,2008,16(9):1567-1571. WANG ZH Q,XU Y. Eye model-based digital fundus camera design[J]. Opt. Precision Eng.,2008,16(9):1567-1571.(in Chinese) [9] 许妍,王肇圻,田野.基于眼模型的折/衍混合眼底相机设计[J].光子学报,2009,38(5):1122-1125. XU Y,WANG ZH Q,TIAN Y. Field based on the eye model of the refractive/diffractive hybrid fundus camera design[J]. Photon Sinica,2009,38(5):1122-1125.(in Chinese) [10] 饶丰.大焦深人工晶体的设计[J].中国光学,2012,5(5):485-492. RAO F. Design of multi-focus intraocular lenses[J]. Chinese Optics,2012,5(5):485-492.(in Chinese) [11] 李蕊,刘永基,王肇圻.基于个体眼光学结构的波前眼镜设计[J].中国光学,2012,5(5):512-519. LI R,LIU Y J,WANG ZH Q. Design of wavefront-guided lens based on individual eye optical model[J]. Chinese Optics,2012,5(5):512-519.(in Chinese) [12] 姚军财.基于人眼对比度敏感视觉特性的彩色图像压缩技术[J].液晶与显示,2012,7(6):800-807. YAO J C. Color image compression technology based on contrast sensitivity characteristics of human vision system[J]. Chinese J. Liquid Crystals and Displays,2012,7(6):800-807.(in Chinese)

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