新生儿黄疸治疗仪用LED光源光谱功率分布匹配

甘汝婷; 郭震宁

doi:10.3788/CO.20140705.0794

新生儿黄疸治疗仪用LED光源光谱功率分布匹配

doi: 10.3788/CO.20140705.0794

甘汝婷,
郭震宁^,

华侨大学信息科学与工程学院, 福建厦门 361021

基金项目:

福建省科技计划重点资助项目（No.2013I0004）

详细信息

作者简介:
甘汝婷（1988- ），女，河南商丘人，硕士研究生，主要从事LED照明与光学设计方面的研究。

通讯作者:
郭震宁，E-mail：znguo@hqu.edu.cn

中图分类号: TN383;R318.51
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- 被引次数: 0
出版历程
- 收稿日期: 2014-04-11
- 修回日期: 2014-06-16
- 刊出日期: 2014-09-25

Spectral power distribution matching for light-emitting diode-based neonatal jaundice therapeutic device

GAN Ru-ting,
GUO Zhen-ning^,

College of Information Science and Engineering, Huaqiao University, Xiamen 361021, China

摘要

摘要: 为了有效降低胆红素脑病的风险和减少换血的需要，以实验测试的标准胆红素溶液最有效的吸收光谱作为光疗的目标光谱，根据光谱构造理论，采用不同峰值波长和半高宽的单色LED作为匹配光源，首次提出简单遗传算法作为光谱匹配算法，通过求解超定方程组的非负最小二乘解，得到最优LED组合比例，进而推得所需各种峰值波长的LED的数量。仿真实验结果表明：拟合的光谱曲线与目标光谱曲线十分近似，光谱匹配度达到了98.39%，获得了一种新型的LED黄疸治疗仪光源光谱功率分布。该算法简单，效率高、拟合误差小，可应用基于LED光源的光谱功率分布匹配技术的研究。
- LED /
- 黄疸治疗仪 /
- 简单遗传算法 /
- 光谱功率分布 /
- 光谱匹配
Abstract: To decrease the risk of bilirubin encephalopathy and minimize the need for exchange transfusion effectively,the most efficient absorption spectrum of standard bilirubin tested by the experiment was regarded as the target spectrum. On the basis of spectral constructing theory, monochromatic light-emitting diodes(LEDs) with different peak wavelength and full width at half maximum(FWHM) were used as matching sources. The simple genetic algorithm(SGA) was first proposed as the spectral matching method in this study. The optimal combination ratios of LEDs were obtained by calculating the non-negative least square of the overdetermined equations. The required LED number at each peak wavelength was then calculated. Simulation experimental results show that the fitting spectrum is very comparable to the target spectrum with 98.39% matching degree, and a new spectral power distribution of LED-based jaundice therapeutic device was obtained finally. With simplicity, high efficiency, and small fitting error, this algorithm is very suitable for the study of LED-based spectral power distribution matching technology.
- light-emitting diode /
- jaundice therapeutic device /
- simple genetic algorithm /
- spectral power distribution /
- spectral matching

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参考文献(1)

[1] CREMER R J, PENYMAN P W, RICHARDS D H. Influence of light on the hyperbilirubinaemia of infants[J]. The Lancet, 1958, 271(7030):1094-1097.
[2] ENNEVER J F, SOBEL M, MCDONAGH A F, et al. Phototherapy for neonatal jaundice: in vitro comparison of light sources[J]. Pediatric Research, 1984, 18(7):667-670.
[3] CHANG Y S, HWANG J H, KWON H N, et al. In vitro and in vivo efficacy of new blue light emitting diode phototherapy compared to conventional halogen quartz phototherapy for neonatal jaundice[J]. J. Korean Medical Science, 2005, 20(1):61-64.
[4] VREMAN H J, WONG R J, STEVENSON D K. Phototherapy:current methods and future directions[J]. Seminars in Perinatology, 2004, 28(5):326-333.
[5] SURMELI-ONAY O, KORKMAZ A, YIGIT S, et al.. Phototherapy rash in newborn infants: does it differ between conventional and light emitting diode phototherapy[J]. Pediatric Dermatology, 2013, 30(5):529-533.
[6] SCHUBERT E F. Light-Emitting Diodes[M]. UK:Cambridge University Press, 2006.
[7] YEH N G, WU C H, CHENG T C. Light-emitting diodes-Their potential in biomedical applications[J]. Renewable and Sustainable Energy Reviews, 2010, 14(8):2161-2166.
[8] HATAKEYAMA T, MURAYAMA Y, KOMATSU S, et al. Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy using light-emitting diodes in human colon cancer cells[J]. Oncology Reports, 2013, 29(3):911-916.
[9] KWON H H, LEE J B, YOON J Y, et al. The clinical and histological effect of home-use, combination blue-red LED phototherapy for mild-to-moderate acne vulgaris in Korean patients: a double-blind, randomized controlled trial[J]. British J. Dermatology, 2013, 168(5):1088-1094.
[10] LIN M H, HUANG M Y, HUANG W D, et al. The effects of red, blue, and white light-emitting diodes on the growth, development, and edible quality of hydroponically grown lettuce[J]. Scientia Horticulturae, 2013, 150: 86-91.
[11] 臧景峰, 朴燕, 宋正勋, 等. 基于白光LED照明光源的室内VLC系统[J]. 发光学报, 2009, 30(6):877-881. ZANG J F, PIAO Y, SONG ZH X, et al. Synthesis of spectral distribution for LED-based source with tunable spectra[J]. Chinese J. Luminescence, 2009, 30(6):877-881.(in Chinese)
[12] 安徽医学院生化教研组编. 临床生化20例[M].合肥:安徽科学技术出版社, 1984. Anhui Medical College Biochemistry Teaching and Research Group. 20 cases of Clinical and Biochemistry[M]. Hefei:Anhui Science and Technology Press, 1984.(in Chinese)
[13] 中国药典委员会编. 中国药典一部[M].北京:人民卫生出版社、化学工业出版社, 1990. Chinese Pharmacopoeia Commission. The First Part of Chinese Pharmacopoeia[M]. Beijing:People's Health Publishing Press, Chemical Industry Press, 1990.(in Chinese)
[14] American Academy of Pediatrics Clinical Practice Guideline Subcommittee on Hyperbilirubinemia. Management of hyperbilirubin in the newborn infant 35 or more weeks of gestation[J]. Pediatrics, 2004, 114(1):297-316.
[15] BHUTANI V K. Phototherapy to prevent severe neonatal hyperbilirubinemia in the newborn infant 35 or more weeks of gestation[J]. Pediatrics, 2011, 128(4):e1046-e1052.
[16] EBBESEN F, MADSEN P, STΦVRING S, et al. Therapeutic effect of turquoise versus blue light with equal irradiance in preterm infants with jaundice[J]. Acta Paediatr, 2007, 96(6):837-841.
[17] GEIDO D, FAIACHE H, SIMINI F. BiliLED low cost neonatal phototherapy, from prototype to industry[J]. J. Physics:Conference Series, 2007, 90(1):012024-1-9.
[18] 刘洪兴, 任建伟, 李葆勇, 等. 基于溴钨灯和LED积分球光源的可调谐光谱分布及光谱匹配[J]. 发光学报, 2011, 32(10):1074-1080. LIU H X, REN J W, LI B Y, et al. Spectrum-tunable distribution and spectral matching for integrating sphere light source based on bromine tungsten lamps and LEDs[J]. Chin. J. Lumin., 2011, 32(10):1074-1080.(in Chinese)
[19] 刘洪兴, 孙景旭, 刘则洵, 等. 氙灯和发光二极管作光源的积分球太阳光谱模拟器[J]. 光学精密工程, 2012, 20(7):1447-1454. LIU H X, SUN J X, LIU Z X, et al.. Design of integrating sphere solar spectrum simulator based on xenon lamp and LEDs[J]. Opt. Precision Eng., 2012, 20(7):1447-1454.(in Chinese)
[20] FRYC I, BROWN S W, EPPELDUER G P. LED-based spectrally tunable source for radiometric, photometric and colorimetric application[J]. Opt. Eng., 2005, 44(11):111309-111316.
[21] FRYC I, BROWN S W, OHNO Y. Spectral matching with an LED-based spectrally tunable light source[J]. SPIE, 2005, 5941:59411I-1-59411I-9.
[22] 卓金武, 魏永生, 秦建, 等.MATLAB在数学建模中的应用[M].北京:北京航空航天大学出版社, 2011, 37-59. ZHUO J W, WEI Y SH, QIN J, et al. The Application of MATLAB in Mathematical Modeling[M]. Beijing:Beihang University Press, 2011, 37-59.(in Chinese)
[23] 孙娟娟, 黄宗潘, 杨大成. 基于模拟退火的移动业务分布预测算法[J]. 电子与信息学报, 2008, 30(9):2225-2228. SUN J J, HUANG Z P, YANG D CH. Algorithms of mobile traffic distribution forecasting based on simulated annealing[J]. J. Electronics Information Technology, 2008, 30(9):2225-2228.(in Chinese)
[24] 朱继亦, 任建伟, 李葆勇, 等. 基于LED的光谱可调光源的光谱分布合成[J]. 发光学报, 2010, 31(6):882-887. ZHU J Y, REN J W, LI B Y, et al.. Synthesis of spectral distribution for LED-based source with tunable spectra[J]. Chin. J. Lumin., 2010, 31(6):882-887.(in Chinese)
[25] SHEN H P, FENG H J, PAN J G, et al.. Mathematical model for LED spectra and application[C]. About CIE 26th China Illuminating Engineering Society Annual Meeting Proceedings, Beijing, China:Illuminating Engineering Society, September 25~27, 2005:83-85.