Abstract: A number of debris in low earth orbit is exponentially growing although future debris release and mitigation measures have been considered in human space activities. Especially, an already existing population of small and medium debris is a concrete threat to operational satellites. Ground-based DF laser and space-based Nd:YAG laser solutions appear as a highly promising answer, which can remove hazardous debris around the selected space assets at low expenses and in a non-destructive way. This paper introduces a research on the Space Vehicle(CV) protection and the orbit clearing from dangerous Elements of Space Debris(ESD) with diameters from 1 to 10 cm by means of a high-power and high repetition rate P-P Nd:YAG laser with an average power of 100 kW and a DF-laser with an average power about 1.5 MW.