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Influence of glucose concentration on blood optical properties in THz frequency range

GUSEV Sviatoslav Igorevich DEMCHENKO Petr S CHERKASOVA Olga P FEDOROV Vyacheslav I KHODZITSKY Mikhail K

GUSEVSviatoslav Igorevich, DEMCHENKOPetr S, CHERKASOVAOlga P, FEDOROVVyacheslav I, KHODZITSKYMikhail K. 葡萄糖浓度对THz频段血液光学特性的影响[J]. 中国光学(中英文), 2018, 11(2): 182-189. doi: 10.3788/CO.20181102.0182
引用本文: GUSEVSviatoslav Igorevich, DEMCHENKOPetr S, CHERKASOVAOlga P, FEDOROVVyacheslav I, KHODZITSKYMikhail K. 葡萄糖浓度对THz频段血液光学特性的影响[J]. 中国光学(中英文), 2018, 11(2): 182-189. doi: 10.3788/CO.20181102.0182
GUSEV Sviatoslav Igorevich, DEMCHENKO Petr S, CHERKASOVA Olga P, FEDOROV Vyacheslav I, KHODZITSKY Mikhail K. Influence of glucose concentration on blood optical properties in THz frequency range[J]. Chinese Optics, 2018, 11(2): 182-189. doi: 10.3788/CO.20181102.0182
Citation: GUSEV Sviatoslav Igorevich, DEMCHENKO Petr S, CHERKASOVA Olga P, FEDOROV Vyacheslav I, KHODZITSKY Mikhail K. Influence of glucose concentration on blood optical properties in THz frequency range[J]. Chinese Optics, 2018, 11(2): 182-189. doi: 10.3788/CO.20181102.0182

葡萄糖浓度对THz频段血液光学特性的影响

详细信息
  • 中图分类号: O441.4;R446.11

Influence of glucose concentration on blood optical properties in THz frequency range

doi: 10.3788/CO.20181102.0182
Funds: 

the Government of Russian Federation 074-U01

More Information
    Author Bio:

    GUSEV Sviatoslav Igorevich(1991-), PhD student, Department of Photonics and Optical Information Technology, ITMO University, Russia.His research interests are in terahertz time-domain spectroscopy, diabetes care, non-invasive glucose measuring, signal processing.E-mail:mail@gusev-spb.ru

    KHODZITSKY Mikhail(1984—), Chief of Terahertz Biomedicine Laboratory, Associate professor, Department of Photonics and Optical Information Technology, ITMO University, Russia. His research interests are in terahertz photonics, metamaterials, biophotonics and terahertz spectroscopy. E-mail:khodzitskiy@yandex.ru

    Corresponding author: KHODZITSKY Mikhail K, E-mail:khodzitskiy@yandex.ru
  • 摘要: 无创性血糖检测仍是糖尿病患者护理安全舒适的现实科学任务。本文研究了血糖光学特性与血糖浓度之间的相关性。用时域THz光谱研究了全血在0.3~0.5 THz频率范围内的透射谱。在注射胰岛素后的短时间内,由同一糖尿病患者产生了生物样品。得到了血液光学特性的频散特性。基于频散,给出了血糖浓度与折射率和介电常数的关系式。这项工作是复杂研究的一部分,重点是无创葡萄糖测量技术的发展。记录血糖水平与血液光学参数之间的依赖关系,使得将来可以使用反射光谱技术进行无创血糖水平检测。

     

  • Figure 1.  Schematic diagram of the setup(FL-1:femtosecond laser based on potassium-yttrium tungstate crystal activated with ytterbium(Yb:KYW), generating femtosecond pulses; F1, 2:a set of teflon filters for IR wavelength range cutting off, BS:beamsplitter, DL:optical delay line, M1, 2, 3:mirrors, Sam:investigated sample, Wol.:Wollaston prism, CdTe:electro optical cadmium-telluric crystal, BD:balanced detector, LA:lock-in amplifier, PC:personal computer, GTP:Glan-Taylor prism, PM1, 2:parabolic mirrors, Ch:chopper, DAC:digital to analog converter, ADC:analog to digital converter

    Figure 2.  (a) The scheme of sample preparation and (b)experimental signals

    Figure 3.  Polymethyl methacrylate(PMMA) container with blood

    Figure 4.  Dispersions of optical parameters of samples with different glucose concentration cglucose: (a)the real part of refractive index nreal(f); (b)the absorption coefficient α(f); (c)the real part of permittivity εreal(f); (d)the imaginary part of permittivity εimag(f)

    Figure 5.  Dependencies of glucose concentration with (a) the real part of refractive index cglusose and (b)with the real part of permittivity cglucose(εreal) at different frequencies

    Table  1.   The list of the glucose concentrations of samples used in experiment

    Sample No. mmol/L mg/dL
    1 3.0 54.0
    2 3.8 68.4
    3 6.2 111.6
    4 9.2 165.6
    5 11.0 198.0
    6 14.9 268.2
    7 18.0 324.0
    8 19.0 342.0
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出版历程
  • 收稿日期:  2017-12-17
  • 修回日期:  2018-02-28
  • 刊出日期:  2018-04-01

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