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Research progress of biosensors based on long period fiber grating

LI Qiu-shun CAI Lei MA Yao-hong YANG Jun-hui YANG Yan MENG Qing-jun SHI Jian-guo

李秋顺, 蔡雷, 马耀宏, 杨俊慧, 杨艳, 孟庆军, 史建国. 长周期光栅生物传感器研究进展[J]. 中国光学, 2018, 11(3): 475-502. doi: 10.3788/CO.20181103.0475
引用本文: 李秋顺, 蔡雷, 马耀宏, 杨俊慧, 杨艳, 孟庆军, 史建国. 长周期光栅生物传感器研究进展[J]. 中国光学, 2018, 11(3): 475-502. doi: 10.3788/CO.20181103.0475
LI Qiu-shun, CAI Lei, MA Yao-hong, YANG Jun-hui, YANG Yan, MENG Qing-jun, SHI Jian-guo. Research progress of biosensors based on long period fiber grating[J]. Chinese Optics, 2018, 11(3): 475-502. doi: 10.3788/CO.20181103.0475
Citation: LI Qiu-shun, CAI Lei, MA Yao-hong, YANG Jun-hui, YANG Yan, MENG Qing-jun, SHI Jian-guo. Research progress of biosensors based on long period fiber grating[J]. Chinese Optics, 2018, 11(3): 475-502. doi: 10.3788/CO.20181103.0475

长周期光栅生物传感器研究进展

doi: 10.3788/CO.20181103.0475
基金项目: 

National Natural Science Foundation of China 61340032

National Natural Science Foundation of China 61535010

National Natural Science Foundation of China 31500858

Natural Science Foundation of Shandong Province ZR2012CM029

Research Development Program of Shandong Province 2016ZDJS07A20

Youth Fund of Shandong Academy of Sciences 2017QN0010

the National High Technology Research and Development Program of China 2015AA021005

详细信息
    作者简介:

    李秋顺(1969—),男,博士,副研究员,山东济南人,2009年获得吉林大学博士学位,主要从事纳米材料合成、光电生化分析等方面的研究。E-mail:lishun1688@126.com

  • 中图分类号: TN253;TB383;TN929.11;O439

Research progress of biosensors based on long period fiber grating

Funds: 

National Natural Science Foundation of China 61340032

National Natural Science Foundation of China 61535010

National Natural Science Foundation of China 31500858

Natural Science Foundation of Shandong Province ZR2012CM029

Research Development Program of Shandong Province 2016ZDJS07A20

Youth Fund of Shandong Academy of Sciences 2017QN0010

the National High Technology Research and Development Program of China 2015AA021005

More Information
    Author Bio:

    LI Qiushi(1969——), male, doctor, associate research fellow, born in Jinan, Shandong. He received a doctor′s degree in Jilin University in 2009. He is engaged mainly the study of nanometer material synthesis, photoelectric and biochemical analysis, etc.E-mail:lishun1688@126.com

    Corresponding author: SHI Jianguo(1960——), male, doctor, research fellow, born in Taian, Shandong. He received a doctor′s degree from Shandong University in 2006. He is engaged mainly in the development of biosensors and the study of real time monitoring etc. in the industrial fermentation process. E-mail:shijg@sdas.org
  • 摘要: 长周期光纤光栅是对周围环境比较敏感的一种无源光学器件,由于其具有无后向反射、对折射率灵敏度高、体积小、易于集成化、不受电磁干扰、耐酸碱腐蚀、不需要参比电极等诸多特点,在折射率传感领域备受关注。自从2000年Bentley研究组第一次将长周期光纤光栅用于抗原的检测以来,经过十余年的发展,长周期光栅在生物物质的检测方面取得了很大的进展,已被用于抗原抗体、细菌病毒、蛋白质、DNA、酶及核酸等诸多生物物质的检测。本文对长周期光纤光栅近年来在生物传感领域的研究进展和应用进行了总结和评述,并对长周期光纤光栅在生物物质检测方面的未来发展趋势做了展望。
  • 图  1  生化试剂在光子晶体光纤-长周期光栅表面作用时所引起的谐振波长移动情况

    Figure  1.  Shift of resonance wavelength of the LPFG-PCF at various surface events

    图  2  涂覆二氧化钛-二氧化硅的长周期光栅生物传感结构示意图

    Figure  2.  Schematic illustration of the optical fiber biosensor based on titania-silica coated LPFG

    图  3  长周期光栅检测DNA过程示意图

    Figure  3.  Schematic representation of DNA detection process using LPFG

    图  4  长周期光栅表面不同生物试剂修饰示意图

    Figure  4.  Sketch of coated LPFG interface with different biological agents

    图  5  磷酸缓冲液中浓度为109 CFU/mL的大肠杆菌在长周期光栅表面固定后的扫描电镜图

    Figure  5.  SEM micrograph of the E.coli immobilized on the surface of the LPFG:109 CFU/mL of E.coli concentration in PBS

    图  6  长周期光栅表面修饰步骤及噬菌体T7检测示意图

    Figure  6.  Schematic representation of the LPFG surface modification steps and phage T7 detection

    图  7  覆盖30 nm二氧化钛薄膜的长周期光栅传感结构示意图

    Figure  7.  Schematic of the sensing configurations for LPFG coated with 30 nm of TiO2

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  • 收稿日期:  2018-01-25
  • 修回日期:  2018-03-13
  • 刊出日期:  2018-06-01

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